When Cy-bug—a robotic, buglike virus—got stranded in the Sugar Rush world, the protagonists faced some serious difficulty finding it. The thick sugar particles in the atmosphere jammed their sensors making it impossible to spot this evil creature. While that can happen in a Wreck-It Ralph universe, the opposites are true in the real world. A recent paper published in ACS Central Science showed a successful development of SARS-CoV-2 detection kit with the help of sugar mixtures.
Lung cancer is the cancer that has claimed the most lives worldwide for decades. Specifically, small cell lung cancer has been difficult to treat due to its ability to rapidly adapt and resist to treatment. In this study, public datasets of small cell lung cancer cells that became resistant after treatment with talazoparib or prexasertib were analyzed using bioinformatic tools to elucidate common processes that allow for treatment refraction. The reactive oxygen species (ROS) pathway and TGF-beta signaling pathway were prominent in the tissues treated with both treatment types. Shared genes contributing to these pathways in both treatments were studied for their role in the development of resistance. Seven genes were identified that should be further tested as potential targets to reverse treatment resistance.
