A keynote on the AIDS epidemic story

A keynote on the AIDS epidemic story

By Arshan Khatri 

There have been many plagues and Pandemics before, affecting people in negative ways. The AIDS Epidemic was an unexpected one, putting the victims at high risk of Immune deficiencies and breaking them down mentally. The Acquired Immune Deficiency Syndrome (AIDS) disease is caused by the HIV viruses, a group of very latent viruses, which makes them more so threatening. AIDS was not just a medical challenge but also a political one. The early 1980s shook the world with the unfolding of one of the most fatal diseases killing around 690,000 humans in 2020. The Good News is that the statistics are decreasing with the advent of modern- day technology, awareness, and prevention efforts.

The AIDS Epidemic was a huge challenge to the Healthcare systems around the world. This disease most likely originated from Western Africa and seemed to have transferred from non- human primates to human beings. This virus then traveled across the world when Africa was colonized and when the sex trade began. It reached United Status; California and New York were its primary targets.

Let’s take a look at the origin of the AIDS Epidemic: The central point of discussion when it comes to HIV in Africa, particularly Western Africa. In Africa, the primates had SIV (Simian Immunodeficiency Virus) strain from the Genus Lentivirus, which seemed to live in harmony with their primate hosts. The main concern is it’s the crossover to the Human; there were many theories proposed as to how did that occur. The most prevalent theory is the ‘Bushmeat Trade’, which involved the hunting of animals especially primates for food and other purposes. The hunters were regularly subjected to the animal’s blood and any cuts or injuries in the hunter’s body led to the mixing of their blood and subsequently the Crossover event occurred. However, the notion that the primates were unaffected by the SIV strain they carried, is challenged today. Most likely, this crossover event took place in the 1930s. In a nutshell, the transfer of these SIV strains from various primates like Chimpanzees and monkeys was the root of a tragic epidemic that would horrify the people of the world after a few decades.

It started among gay men in LA and San Francisco. The symptoms were that of Pneumocystis Pneumonia (PCP) and a cancer type called Kaposi Sarcoma was also diagnosed. Not only gay men but people who used intravenous drugs were also vulnerable to catching HIV. At first, the CDC or the Center for Disease Control and prevention couldn’t understand much and they needed funding from the government to do research; they were made fun of in the press for reporting an epidemic that was prevalent amongst gay men. It was too late; People were dying in big numbers.

The government was too late to help. After the president approved the funds, the research began nationwide, collecting data. Drugs were proposed like the AZT. Clinical trials were conducted to check the usability of these drugs but the people were inpatients. They pledged against the NIH and formed support groups like ACT UP owing to the disconnect between the scientific community and the regular people.

As the studies occurred, the understanding of AIDS cleared more and more. In the beginning, AIDS was the subject of stigmatization and mockery by regular people. AIDS patients like 13- year-old Ryan White were not allowed to attend public places and refrained to attend schools. Soon though this changed, people began to mature and understand the scale and threat of this global Epidemic.

Talking about treatments-many treatments like HAART, Stem Cell Transplant and Bone Marrow Transplant are being practiced. There are constant efforts made to educate people about

precautions, treatments, sexual behaviour, and more to undo the errors of the past. Unfortunately, the deaths that happened due to the carelessness of government officials, people, and healthcare workers couldn’t be undone. Slowly but surely, the future is looking promising for AIDS considering the breakthroughs in health care systems, public support, and governmental aid. We can only get better at it if only the patients, doctors, people, and government work together in harmony.

References

  1. hiv.gov Global statistics 2020

  2. Morbidity & Mortality Weekly Report. Kaposi's sarcoma and pneumocystis pneumonia

    among homosexual men - New York City and California. MMWR Weekly 1981. 30:

    305–308.

  3. Center for Disease Control (CDC) (1981) 'Kaposi's Sarcoma and Pneumocystis

    Pneumonia among Homosexual Men- New York City and California' MMWR

    Morbidity and Mortality Weekly Report 30(25):305-308.

  4. A history of AIDS: Looking back to see ahead. Eur. J. Immunol. 2007. 37: S94–102

  5. Ryan White: My own story. Biography (1991)

  6. AIDS Epidemic—Origin, mechanism, stigmas, American struggles, mental issues and

    cure, Curieux Academic Journal, May 2022 issue PG no. 43-57 by Arshan Khatri.

Safeguarding People from Harmful Medicines

Safeguarding People from Harmful Medicines

Author: Septia Nurmala


Chances are you’ve taken Tylenol before to treat your headache. Or Pepto Bismol when you had an upset stomach. Or maybe you’ve bought these drugs just because the ads were visually compelling? Behind every medicine you take, there’s a public health body whose job is to make sure the medicines you consume are safe and effective. This agency works around the clock to evaluate everything — from new drug applications to how they’re advertised so as not to overclaim and mislead the public.


Earlier this year in March, I had the opportunity to intern in Indonesia’s National Food and Drug Control, or better known in the US as Food and Drug Agency (FDA). I was hoping to be placed in The Office of Drug Registration, as I was very interested to learn more about the rise of Emergency Use Authorization during the pandemic and the case for fast-tracked approval which seems buzzing for rare disease drugs nowadays. But alas, I was placed in a department that handles something more elusive than what the pandemic has put in the limelight: The Office of Pharmaceuticals, Narcotics, Psychotropics, Precursors, and Addictive Substances Safety, Quality, and Export Import Supervision. Don’t get intimidated by the long name though! I will break down what the Indonesia’s FDA Office has taught me during my 4 weeks stay with them.


You might've met a neighbor telling you not to get vaccinated because it's unsafe. Drug - and vaccine - safety issues have been around for a long time, but the moment that defines the importance of drug safety goes way back to the era of post-World War II in Germany. During that time, soldiers took Thalidomide to help them cope with sleeping difficulty as a lot of them experienced the abysmal event of war. Thalidomide was a great sedative and tranquilizer; it quickly gained another approval for treating morning sickness in pregnant people early 1950. A few years later, cases of babies born with defects started piling up. No one had any idea what caused it until, in 1961, an Australian doctor published a letter to The Lancet drawing a connection between Thalidomide use and the harm for fetal development.


This accident forces drug regulators around the world to change their practice. Not only do they OK drugs based solely on the data of effectiveness, but they also need to mind the safety if drugs were to be approved. Then, what about Thalidomide or any other drug that has been approved and marketed long before knowing the risk associated with a certain group of people? That's where the drug safety department steps in. The US FDA, under the Center for Drug Evaluation and Research (CDER), has an office dedicated to evaluate post-market drug safety in The Office of Surveillance and Epidemiology (OSE). One of their many tasks - similar to the Indonesian or any other countries’ FDA - is to assess and mitigate the risks of certain drug usage. There are a myriad of ways to do this, and one of them is through what is called spontaneous or voluntary reporting.


Shortly after the recall of Thalidomide from the market, drug regulators agreed upon a standardized way to report adverse events should healthcare workers, pharmaceutical industries, distributors, or patients want to report one. Per the US FDA website, people in the US can report any adverse events online through the FDA MedWatch program, use a consumer or healthcare reporting form, or call the FDA office directly. Specifically for vaccines, consumers can report adverse events following vaccinations online to the Vaccine Adverse Event Reporting System (VAERS). Bear in mind the information that needs to be on hand when you try to report though. In order for drug regulators to evaluate your report, they’ll need details on patient information; the adverse event you feel; product problem and availability —- basically telling the FDA if the drug suspect is approved; list of any suspect products including other concomitant drugs or multivitamins you take; and who reports it. The more information you give, the more you help the office determine if it is indeed an adverse event caused specifically by drug or vaccine products.


The story of Thalidomide is one that is headline grabbing, but adverse events happen anytime around us. Even mild nausea post-medication can be included as an adverse event when enough data points so. Next time you see someone experiencing anaphylactic reaction after taking a penicillin antibiotic or a rash after consuming a certain type of drugs, report them to your respective FDA office, even if you’re unsure whether the drug caused it or if it is merely the act of other culprits. They need every bit of data you can offer to infer the causality because only through data can we take actions and shape policies. And what regulatory actions would the FDA take to mitigate the risk? And what are the tasks of other offices during my internship? Stay tuned for our next JYI Blog 😉.


Further reading:

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On Intersectionality in Healthcare

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Premed Burnout and Medical Education

Premed Burnout and Medical Education

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10 Traits of a Great Leader

10 Traits of a Great Leader

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To Break Out From Your Own Shell: My Journey in Japan

To Break Out From Your Own Shell: My Journey in Japan

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10 Tips to Avoid Burnout

10 Tips to Avoid Burnout

Burnout amongst scientists and physicians is a silent epidemic.

Teenage and young adult suicide rides have continued to rise, and mental health issues are a pressing issue among undergraduate and high school studies. Our universities and workplaces have become a hunting ground for competition and bullying. Meanwhile, the amount of knowledge and skills required to succeed in the biomedical sciences have exponentiated. Coupled with an ever more difficult funding environment, training pathways and copious documentation for healthcare professionals, it becomes ever more important to address burnout for those in the biomedical field. I write about burnout not because I have the perfect solution to offer, but because it is a struggle I face every day.

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Surviving and thriving off a four-hour commute

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Making the jump from undergraduate to graduate studies may inspire intense feelings of accomplishment, pride, happiness, and … imposterism?  Newly minted graduates who are stepping into higher degree programs often report feeling like an “imposter” in a sea of other graduate students who appear to be more intelligent, more qualified, and more capable of meeting all the requirements of a graduate degree.  Often, these students feel like they are a fraud, someone who does not belong in such a group of highly intelligent individuals, and that it is just a matter of time before other people realize this too.  These feelings are referred to as Imposter Syndrome, which affects both female and male graduate students.

Using CRISPR in my kitchen

Using CRISPR in my kitchen

Clustered regularly interspersed short palindromic repeats- or the far catchier CRISPR for short is often described as ‘precise molecular scissors’. Parts of the system were first noted over 30 years ago but only recently has it been put together as an interesting example of bacteria protecting themselves against viruses. Having genetically modified bacteria before, I was curious to try the new technology myself so I ordered the basic CRISPR kit sold by The Odin and tried it out in my kitchen!

Making the Most of Your Summer Research

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